大学院生のページ

大学院生による学会発表

2016

【国際学会での発表】

Francis Mwimanzi1,Macdonald Mahiti1,2, Toyoda Mako1, Jaclyn K Mann3, Thumbi Ndung’u3, Takamasa Ueno1, 2 1Center for AIDS Research and 2International Research Center for Medical Sciences, Kumamoto University, 2HIV Pathogenesis Programme,University of KwaZulu-Natal, Durban, South Africa.Immunological consequence of Nef-mediated HLA class I downregulation in vivo.

Keystone Symposia HIV Vaccines (X8), March 20-24, 2016.

2015

【国際学会での発表】

Kamori D, Murakami T, Hasan Z, Meribe S,  Carlson J, Siarot L, Miura T, Kawana-Tachikawa  A, Iwamoto A, Gatanaga H, Oka S, Aida Y, Ueno T. Effects of natural variability of Vpr on immunological footprints and protein functions. Keystone Symposia HIV Vaccines (X5), March 22-27, 2015.

 

2014

【国際学会での発表】

Stanley C. Meribe, Zafrul Hasan, Hiroyuki Gatanaga, Toshiyuki Miura, Ai Kawana-Tachikawa, Aikichi Iwamoto, Shinichi Oka, Takamasa Ueno. Linkage between disease status and a naturally-arising mutation in functional region of HIV-1 Nef. The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014), March 3-6, 2014, Boston, Massachusetts, USA.

【国内学会・セミナー等での発表】

Mahiti M, M. Toyoda M, Mwimanzi F, Walker BD, Brumme ZL, Brockman MA, Ueno T.  HIV-1 Nef differentially recognizes the cytoplasmic tails of HLA-A and HLA-B molecules for down-regulation. The 43rd Annual Meeting for Japanese Society of the Immunology. Kyoto, Japan, Dec 10-12, 2014

 

Kamori D, Murakami T, Hasan Z, Meribe S,  Carlson J, Siarot L, Miura T, Kawana-Tachikawa  A, Iwamoto A, Gatanaga H, Oka S, Aida Y, Ueno T. Effects of natural variability of an immunodominant Vpr region on immunological footprints, clinical outcome and protein functions. The 62nd Annual Meeting of the Japanese Society for Virology, Nov 10-12, 2014.

 

Mahiti M, Toyoda M, Mwimanzi F, Walker BD, Brumme ZL, Brockman MA. Ueno T. Naturally- isolated HIV-1 Nef differentially recognize the cytoplasmic tails of HLA-A and HLA-B molecules for down-regulation. 15th Kumamoto AIDS Seminar, Kumamoto, Japan. Oct 01-03, 2014 

 

Doreen Kamori, T. Murakami, Z. Hasan, J. Carlson, L. Siarot, T. Miura, A. Kawana-Tachikawa, A. Iwamoto, H. Gatanaga, S. Oka, Y. Aida, T. Ueno. Effects of naturally-arising mutations in HLA-A*02-restricted immunodominant region on the functions of HIV-1 Vpr、第16回白馬シンポジウムin熊本、山崎記念会館、2014年6月13日‐14

 

Macdonald Mahiti, M.Toyoda, F.Mwimanzi, B.D.Walker, Z.L.Brumme, M.A.Brockman, T. Ueno. Natural variability of HIV-1 Nef responsible for selective recognition of the HLA-A over HLA-B molecules for down-regulation、第16回白馬シンポジウムin熊本、山崎記念会館、2014年6月13日‐14

 

2013 

【国際学会での発表】 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Differential Nef-mediated down-regulation of HLA-A and B in chronic HIV-1 infection. Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2), [Breckenridge, Colorado USA]  April 3 - April 8, 2013

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules. Frontiers of Retrovirology conference, at Churchill College, Cambridge, UK. September 16th -18th 2013

 

【国内学会・セミナー等での発表】 

本園千尋, John J. Miles, Zafrul Hasan, 潟永博之, Stanley C. Meribe, David A. Price,岡慎一, 宮澤正顕, Andrew K. Sewell, 上野貴将: T細胞の交差反応性とHIV逃避変異の解析、白馬シンポジウム、7月19~20日、名古屋

 

 

2012 

【国際学会での発表】 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, S. Oka, Z. Brumme, Takamasa Ueno. Impact of HLA class I-driven genetic variability in HIV-1 accessory gene vpu. COLD SPRING HARBOR ASIA CONFERENCES: Frontiers of Immunology in Health and Disease. Suzhou Dushu Lake Conference Center, China. September 3 - 7, 2012.

 

【国内学会・セミナー等での発表】 

本園千尋、John J. Miles、宮澤正顯、上野貴将、Andrew K. Sewell: HLA-B35拘束性HIV特異的TCRは野生型抗原に高い特異性を有する、学術賞ならびに学術奨励賞候補口演、第21回組織適合性学会大会、明治大学、東京、2012年9月15~17日

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, Takamasa Ueno. HLA class I-mediated sequence polymorphism in HIV-1 accessory protein Vpu. The 13th KUMAMOTO AIDS Seminar and GCOE Joint International Symposium, Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel, Kumamoto, Japan. October 24-26, 2012.

 

M. Mahiti, P. Mwimanzi, Y. Ogata, M. Tokunaga, B. Walker, Z. Brumme, M. Brockman, T. Ueno. Modulation of HIV-1 Nef-mediated HLA class I down-regulation activity during disease progression. 13th Kumamoto AIDS seminar Aso Resort Grandiovrio Hotel, Kumamoto, Japan 24th -26th October, 2012.

 

Chihiro Motozono, John J. Miles Zafrul Hasan Hiroyuki Gatanaga, Meribe Stanley. C, Shinichi Oka, Masaaki Miyazawa, Andrew K. Sewell, and Takamasa Ueno. HIV-1 immune escape and cross-reactivity profiles of virus-specific cytotoxic T lymphocytes, YIS-A Session II, 13th Kumamoto AIDS Seminar Global COE Joint International Symposium, Aso Resort GRANDVRIO, Kumamoto, Japan, October 24-26, 2012

 

Chihiro Motozono, John S. Bridgeman, Masaaki Miyazawa, Andrew K. Sewell and Takamasa Ueno. The impact of a single amino acid difference in CDR3a on TCR ab cross-reactivity、ワークショップ32 ヒト免疫、第41回日本免疫学会総会・学術集会、神戸、兵庫、2012年12月5~7日

 

 

2011 

【国際学会での発表】 

Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno Impairment of virion infectivity by nef alleles from HIV elite controllers. Keystone Symposia HIV Evolution, Genomics and Pathogenesis (X7), Whistler Conferene center, Whistler, Canada, March 20-25, 2011.

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, T. Ueno. Impact of HLA class I-driven genetic variability in HIV-1 accessory genes in Japanese sequences. Keystone Symposia HIV Evolution. Genomics and Pathogenesis (X7): Whistler Conference Centre, Whistler, Canada; March 20 - 25, 2011.

 

Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno Impairment of virion infectivity by nef alleles from HIV elite controllers. Nef activity in enhancement of virion infectivity is impaired in HIV elite controllers. XV, International Congress of Virology, Sapporo, Japan, 11-16 September 2011.

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, T. Ueno. Effect of HLA class I-mediated selective pressure on HIV-1 accessory genes. International Union of Microbiological Societies 2011 Congress: Virus and host response, Sapporo Convention Center, Sapporo, Japan; September 11-16, 2011.

 

Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman,Takamasa Ueno Impairment of viral replication capacity by nef alleles from HIV elite controllers. Frontiers of Retrovirology, Complex retroviruses, retroelements and their hosts, Amsterdam, Netherlands, 3-5 October 2011.

 

【国内学会・セミナー等での発表】 

Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Population analysis of viral replication capacity by nef alleles of HIV elite controllers. 12th Kumamoto AIDS Seminar, Kumamoto, Japan, 19-21 October 2011.

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, T. Ueno. Subtle effect of HLA class I-driven selective forces on the variability of HIV-1 accessory genes. 12th Kumamoto AIDS Seminar and GCOE Joint International Symposium. Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel, Kumamoto, Japan; October 19-21, 2011.

 

Chihiro Motozono, John J. Miles, Linda Wooldridge, David A. Price, Takamasa Ueno, Andrew K.Sewell. The cross-reactivity footprints of HIV-specific CTLs. 12th Kumamoto AIDS Seminar and GCOE Joint International Symposium. Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel, Kumamoto, Japan; October 19-21, 2011.

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, T. Ueno. Impact of HLA class I-driven genetic variability in HIV-1 accessory genes. 2011 The Annual Meeting of the Japanese Society for Immunology. Chiba, Makuhari Messe, Japan; November 27-30, 2011

 

Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Impaired viral infectivity and viral replication capacity by nef alleles from HIV elite controllers. 25th Annual Meeting of Japanese Society for AIDS Research, Tokyo Hyatt Regency, Tokyo, Japan. November 30th - 2nd December, 2011.

 

 

2010 

【国際学会での発表】 

Mwimanzi P., Masafumi T., and Ueno T. CTL-escape Nef variants influence CCR5 down-regulation and HIV superinfection susceptibility. Keystone Symposia HIV Vaccines (X5), Fairmont Banff Springs, Banff, Alberta, Canada, March 21-26, 2010.

 

Mwimanzi P., Ueno T. CTL-escape Nef variants influence CCR5 down regulation and HIV superinfection susceptibility. The 14th International Conference of Immunology (ICI), Kobe International Exhibition and Portopia Hotel, Kobe, Japan, August 23-27, 2010.

 

【国内学会・セミナー等での発表】 

Mwimanzi, P., Hassan R., Suzu S., Takiguchi M., Ueno T.  The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages. 1st International Young Investigator Symposium, Gene Laboratory, Kumamoto University lecture hall, Center for AIDS Research, Kumamoto University, Kumamoto, Japan, March 4-5, 2010.

 

Mwimanzi, P., Oniangue-Ndza, C., Allen T.M., and Ueno,T. Nef activity in down regulation of viral receptors and protection of HIV superinfection is modulated by Nef mutations that confer CTL escape during acute infection. 11th KUMAMOTO AIDS Seminar GCOE Joint International Symposium, Hotel Nikko Kumamoto and Aso Grand Vrio Hotel, Kumamoto, Japan, October 6-8, 2010.

 

Zafrul Hasan, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Implication of the effects of host immune responses on the HIV-1 vpu gene evolution. The 11th KUMAMOTO AIDS Seminar and GCOE Joint International Symposium. Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel, Kumamoto, Japan; October 6-8, 2010.

 

Zafrul Hasan, Hiroyuki Gatanaga, Shinichi Oka, and Takamasa Ueno. Implication of the effects of host immune responses on the HIV-1 vpu gene evolution. 24th Annual Meeting of the Japanese Society for AIDS Research. Grand Prince Hotel Takanawa, Prince Sakura Tower, Takanawa, Tokyo; November 24-26, 2010.

 

 

2009 

【国際学会での発表】 

Chihiro Motozono, Masafumi Takiguchi, Takamasa Ueno

Specificity-dependent cross reactive capacity of HIV-specific CTLs, The 96th Annual Meeting The American Association of Immunologists (Seattle, USA) May 8-12, 2009.

 

【国内学会・セミナー等での発表】 

本園 千尋、谷中 冴子、津本 浩平、滝口 雅文、上野 貴将: T細胞レセプターのHIV抗原変異に対する交差反応性、第9回日本蛋白質科学会年会(熊本)、平成21年5月20日~5月2日

 

Mwimanzi Philip, Hassan Ranya, Suzu Shinya, Takiguchi Masafumi, Ueno Takamasa. 10th Kumamoto AIDS Seminar-GCOE Joint International Symposia, Hotel Nikko, Kumamoto, Japan. September 28-29, 2009. Presented poster titled: The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.

 

Chihiro Motozono, Masafumi Takiguchi and Takamasa Ueno. The epitopes dictate the cross reactive capacity of HIV-specific CTLs towards variant antigens, 10th AIDS Seminar in Kumamoto (Kumamoto, Japan) September 28-29, 2009. 

 

Philip Mwimanzi, Masafumi Takiguchi, and Takamasa Ueno. 23rd Annual Meeting of Japanese Society for AIDS Research, Nagoya Congress Center, Nagoya, Japan November 26-28, 2009. Presented oral presentation titled: CTL escape Nef variants influence CCR5 down regulation and HIV superinfection susceptibility in primary human macrophages.

 

Chihiro Motozono, Masafumi Takiguchi and Takamasa Ueno. Determinant of the cross reactive capacity of HIV-specific CTLs towards variant antigens、第39回日本免疫学会学術集会(大阪)、平成21年12月2日~4日

 

 

2008 

【国内学会・セミナー等での発表】 

Chihiro Motozono, Masafumi Takiguchi, Takamasa Ueno. The decay of peptide-MHC complex influences antiviral activity of HIV-specific CTLs, 9th AIDS Seminar in Kumamoto, September 18-19, 2008, Kumamoto, Japan

 

本園 千尋、滝口 雅文、上野 貴将 HIV特異的T細胞の抗原特異性と抗原変異に対する交差反応性、第56回日本ウイルス学会学術集会、2008年10月26~28日、岡山

 

Chihiro Motozono, Masafumi Takiguchi and Takamasa Ueno. The decay of peptide-MHC complex influences antiviral activity of HIV-specific CTLs、第38回日本免疫学会学術集会、2008年12月1日~3日、京都

 

 

2007 

【国内学会・セミナー等での発表】 

本園 千尋、滝口 雅文、上野 貴将 T細胞の抗ウイルス機能制御に関わる抗原ペプチドのタンパク科学的特性の解析、第7回日本蛋白質科学会年会、2007年5月24日~5月2日、仙台

 

本園 千尋、滝口 雅文、上野 貴将 T細胞の抗ウイルス機能とTCR-pMHC相互作用、第17回Kyoto T Cell Conference、2007年6月15日~6月16日、京都

 

Chihiro Motozono, Masafumi Takiguchi, Takamasa Ueno. The capacity of antigenic peptides that dictates antiviral activity of Cytotoxic T Lymphocytes, 8th AIDS Seminar in Kumamoto, September 13-14, 2007, Kumamoto, Japan

 

 

2006 

【国際学会での発表】 

Chihiro Motozono, Masafumi Takiguchi and Takamasa Ueno

Different cytotoxic T lymphocyte activity and competitive antigen presentation toward two HIV-1 Nef epitopes, one of which is entirely contained within the other, Second Conference on Measuring Antigen-Specific Immune Responses (Santorini, Greece), June 14-17, 2006.

 

【国内学会・セミナー等での発表】 

本園 千尋、滝口 雅文、上野 貴将 HIV抗原とT細胞レセプターの相互作用によるT細胞の抗ウイルス機能制御 第6回日本蛋白質科学会年会、2006年4月24日~4月26日、京都

 

Chihiro Motozono, Masafumi Takiguchi and Takamasa Ueno. Different cytotoxic T lymphocyte activity and competitive antigen presentation toward two HIV-1 Nef epitopes, one of which is entirely contained within the other, 7th AIDS Seminar in Kumamoto, September 21-22, 2006, Kumamoto, Japan

 

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