メンバー紹介
研究業績リスト
1. Takamasa Ueno, Kenji Oosawa& Shin-IchiAizawa (1992) M ring, S ring and proximal rod of the flagellar basal body of Salmonella typhimurium are composed of subunits of a single protein, FliF.Journal of Molecular Biology 227, 672-677
2. Takamasa Ueno, Kenji Oosawa& Shin-IchiAizawa (1994)Domain structures of the MS ring component protein (FliF) of the flagellar basal body of Salmonella typhimurium.Journal of Molecular Biology 236, 546-555
3. Kenji Oosawa, Takamasa Ueno& Shin-IchiAizawa (1994)Overproduction of the bacterial flagellar switch proteins and their interactions with the MS ring complex in vitro.Journal of Bacteriology 176, 3683-3691
4. Mary C. O'Brien, Takamasa Ueno, NazmaJahan, Maria Zajac-Kaye & Hiroaki Mitsuya (1995)HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells.Biochem. Biophys. Res. Comm. 207, 903-909
5. Takuma Shirasaka, Mark F. Kavlick, Takamasa Ueno, Wen-Yi Gao, Eiji Kojima, Maria L. Alcaide, SudhichaiChokekijchai, Birgit M. Roy, Edward Arnold, Robert Yarchoan& Hiroaki Mitsuya (1995)Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides.Proc. Nat'l. Acad. Sci. U.S.A. 92, 2398-2402
6. Takamasa Ueno, Takuma Shirasaka& Hiroaki Mitsuya (1995)Enzymatic characterization of human immunodeficiency virus type 1 reverse transcriptase resistant to multiple 2',3'-dideoxynucleoside 5'-triphosphates.Journal of Biological Chemistry 270, 23605-23611
7. Takamasa Ueno& Hiroaki Mitsuya (1995)Current status of the development of HIV protease inhibitors and their clinical potential.Clinical Immunotherapeutics 4, 451-461
8. Takamasa Ueno& Hiroaki Mitsuya (1997)Comparative enzymatic study of HIV reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single nucleotide incorporation assay.Biochemistry 36, 1092-1099
9. Masatoshi Tanaka, Ranga V. Srinivas, Takamasa Ueno, Mark F. Kavlick, Ferdinand K. Hui, Arnold Fridland, John S. Driscoll & Hiroaki Mitsuya (1997)In vitro induction of human immunodeficiency virus type 1 variants resistant to 2'--fluoro-2',3'-dideoxyadenosine.Antimicrobial Agents and Chemotherapy 41, 1313-1318
10. T. Saito, Takamasa Ueno, Tomoko Kubori, Shigeru Yamaguchi, Tetsuo Iino & Shin-IchiAizawa (1998)Flagellar filament elongation can be impaired by mutations in the hook protein FlgE of Salmonella typhimurium: a possible role of the hook as a passage for the anti-sigma factor FlgM.Molecular Microbiology 27, 1129-1140
11. Lisa F. Rezende, Kenneth Curr, Takamasa Ueno, Hiroaki Mitsuya&Vinayaka R. Prasad (1998)The impact of multidideoxynucleoside resistance-conferring mutations in human immunodeficiency virus type 1 reverse transcriptase on polymerase fidelity and error specificity.Journal of Virology 72, 2890-2895
12. Masatoshi Tanaka, Koichi Takahashi, Takeshi Saika, Intetsu Kobayashi, Takamasa Ueno&JoichiKumazawa (1998)Development of fluoroquinolone resistance and mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae isolates in Japan.Journal of Urology 159, 2215-2219
13. Yoshiyuki Mizushina, Takamasa Ueno, YusoGoto, Yoshiaki Isobe, MagoichiSako, Takehito Fujita, KosakuHirota, Hideya Hayashi &KengoSakaguchi (1998) Carboxyflavins, novel inhibitors of Taq DNA polymerase. International Journal of Molecular Medicine 2, 283-286
14. R.E. Humphrey, K.M. Wyvill, B-Y. Nguyen, L.E. Shay, D.R. Kohler, S.M. Steinberg, Takamasa Ueno, T. Fukazawa, M. Shintani, H. Hayashi, H. Mitsuya& R. Yarchoan (1999) A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection.Antiviral Res. 41, 21-33
15. Tsutomu Mimoto, Ryohei Kato, HaruoTakaku, Satoshi Nojima, Keisuke Terashima, Satoru Misawa, Tominaga Fukazawa, Takamasa Ueno, Hideharu Sato, Makoto Shintani, Yoshiaki Kiso&Hideya Hayashi (1999)Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatineJournal of Medicinal Chemistry 42, 1789-1802
16. Kazuhisa Yoshimura, Ryohei Kato, Keisuke Yusa, Mark F. Kavlick, Victor Maroun, Aline Nguyen, Tsutomu mimoto, Takamasa Ueno, Makoto Shintani, Judith Falloon, Henry Masur, Hideya Hayashi, John Erickson & Hiroaki Mitsuya (1999)JE-2147: a novel dipeptide protease inhibitor (PI) that potently inhibits multi-PI resistant HIV-1.Proc. Nat'l. Acad. Sci. U.S.A. 96, 8675-8680
17. Takamasa Ueno,Hirotada Takahashi, Masako Oda, Makiko Mizunuma, Akihisa Yokoyama, YusoGoto, Yoshiyuki Mizushina, KengoSakaguchi&Hideya Hayashi (2000) Inhibition of human telomerase by rubromycins: implication of spiroketal system of the compounds as an active moiety. Biochemistry 39, 5995-6002
18. *Takamasa Ueno, Satoru Misawa, Yoichi Ohba, Mitsuhiro Matsumoto, Makiko Mizunuma, Nobuhiro Kasai, KouheiTsumoto, Izumi Kumagai&Hideya Hayashi (2000) Isolation and characterization of monoclonal antibodies that inhibit hepatitis C virus NS3 protease. Journal of Virology 74, 6300-6308
19. Tsutomu Mimoto, Naoko Hattori, HaruoTakaku, SumitsuguKsanuki, Tominaga Fukazawa, Keisuke Terashima, Ryohei Kato, Satoshi Nojima, Satoru Misawa, Takamasa Ueno,Junya Imai, Hiroshi Enomoto, Shigeki Tanaka, Hiroshi Sakikawa, Makoto Shintani, Hideya Hayashi & Yoshiaki Kiso (2000) Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonylisostere. Chem. Pharm. Bull 48, 1310-1326
20. Yoshiyuki Mizushina, Takamasa Ueno, Masako Oda, Toyofumi Yamaguchi, MineoSaneyoshi&KengoSakaguchi (2000) The biochemical mode of inhibition of DNA polymerase by -rubromycin. Biochimica et BiophysicaActa 1523, 172-181
21. YusoGoto, Yoshifumi Inoue, Masami Tsuchiya, Masakazu Isobe, Takamasa Ueno, Hiroshi Uchi, MasutakaFurue&Hideya Hayashi (2000) Suppressive effect of topically applied CX-659S, a novel diaminouracilderivative, on the contact hypersensitivity reaction in various animal models. Int. Arch. Allergy Immunol. 123, 341-348
22. Nobuhiro Kasai, KouheiTsumoto, ShinpeiNiwa, Satoru Misawa, Takamasa Ueno,Hideya Hayashi, and Izumi Kumagai (2001) Inhibition of the hepatitis C virus NS3 protease activity by Fv fragment of antibody 8D4. Biochem. Biophys. Res. Comm. 281, 416-424
23. M. Mizunuma, S. Fujimori, H. Ogino, Takamasa Ueno,H. Inoue, N. Kamatani(2001) A recurrent large Alu-mediated deletion in hypoxanthine phosphoribosyltransferase gene associated with Lesch-Nyhan Syndrome. Human Mutation 18, 435-443
24. Yuji Sobao, Hiroko Tomiyama, Kazuhiro Sugi, Michiyo Tokunaga, Takamasa Ueno, Satoru Saito, Shigetoshi Fujiyama, Manabu Morimoto, Katsuaki Tanaka, MasafumiTakiguchi (2002) The role of hepatitis B virus-specific memory CD8 T cells in the control of viral replication. Journal of Hepatology 36, 105-115
25. MansoorAhsan, Yanzhi Yin, Takamasa Ueno,MasafumiTakiguchi, Hideaki Tanaka (2002) Structural analysis of chick ephrin-A2 by function-blocking and nonblocking monoclonal antibodies. Biochem. Biophys. Res. Comm. 295, 348-353
26. Masako Oda, Takamasa Ueno, Nobuyuki Kasai, Hirotada Takahashi, Hiromi Yoshida, Fumio Sugawara, KengoSakaguchi, Hideya Hayashi and Yoshiyuki Mizushina (2002) Inhibition of telomerase by linear-chain fatty acids: A structural analysis. Biochem. J. 367, 329-334
27. KouheiTsumoto, Satoru Misawa, Yoichi Ohba, Takamasa Ueno,Hideya Hayashi, Nobuhiro Kasai, Hideki Watanabe, Ryutaro Asano, Izumi Kumagai (2002) Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target. FEBS Letters 525, 77-82
28. Takamasa Ueno, Hiroko Tomiyama, MasafumiTakiguchi (2002) Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA class I molecules. Journal of Immunology 169, 4961-4969
29. Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi, Oka, MasafumiTakiguchi (2003) HLA class I-restricted recognition of an HIV-derived epitope peptide by a human T cell receptor chain having a V1 variable segment. European Journal of Immunology, 33, 2910-2916
30. Takamasa Ueno, Hiroko Tomiyama, Mamoru Fujiwara, Shinichi, Oka, MasafumiTakiguchi (2004) Functionally impaired HIV-specific CD8 T cells show high affinity TCR-ligand interactions. Journal of Immunology 173, 5451-5457
31. *Takamasa Ueno, Mamoru Fujiwara, Hiroko Tomiyama, Masafumi Onodera, MasafumiTakiguchi (2004) Reconstitution of anti-HIV effector functions of primary human CD8 T lymphocytes by transfer of HIV-specific TCR genes. European Journal of Immunology 34, 3379-3388
32. *Takamasa Ueno, Yuka Idegami, ChihiroMotozono, Shinichi, Oka, MasafumiTakiguchi (2007) Altering effects of antigenic variations in HIV-1 on antiviral effectiveness of HIV-specific CTLs. Journal of Immunology 178, 5513-5523
33. *Takamasa Ueno,ChihiroMotozono, SachiDohki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi, Oka, MasafumiTakiguchi (2008) CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef. Journal of Immunology 180, 1107-1116
34. Tetsuo Tsukamoto, SachiDohki, Takamasa Ueno, Miki Kawada, Akiko Takeda, MichioYasunami, TaekoNaruse, Akinori Kimura, MasafumiTakiguchi, and TetsuroMatano (2008) Determination of a major histocompatibility complex class I restricting simian immunodeficiency virus Gag241-249 epitope. AIDS22, 993-994
35. ChihiroMotozono, SaekoYanaka,KouheiTsumoto,MasafumiTakiguchi,*Takamasa Ueno(2009) Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral acivity of HIV-specific CTL. Journal of Immunology182, 5528-5536
36. Zheng N, Fujiwara M, Ueno T, Oka S, Takiguchi M. (2009) Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress HIV-1 replication in HIV-1-infected CD4+ T cells and macrophages.Journal of Virology 83, 7668-7677
37. Ranya Hassan, Shinya Suzu, MasateruHiyoshi, Naoko Takahashi-Makise, TakamasaUeno, Tsutomu Agatsuma, Hirofumi Akari, Jun Komano, Yutaka Takebe, KazuoMotoyoshi, and Seiji Okada (2009) Dys-regulated activation of a Srctyroine kinase Hck at theGolgi disturbs N-glycosylation of a cytokine receptor Fms. Journal of Cellular Physiology, 221, 458-468
38. Koizumi H, Hashimoto M, Fujiwara M, Murakoshi H, Chikata T, Borghan MA, Hachiya A, Kawashima Y, Takata H, Ueno T, Oka S, Takiguchi M. (2010) Different in vivo effects of HIV-1 immunodominant epitope-specific CTLs on selection of escape mutant viruses.Journal of Virology 84, 5508-5519
39. ChihiroMotozono, Philip Mwimanzi,*Takamasa Ueno (2010) Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection. Protein & Cell1, 514-519
