研究成果

主な学会発表

2016年

Mako Toyoda, Doreen Kamori, Takamasa Ueno,  Naturally Occurring HLA-Associated Nef Polymorphisms that are associated with decreased plasma viral load and impaired Nef-mediated enhancement of virion infectivity, Cold Spring Harbor Laboratory: Retroviruses, May 23(Wed) - 28(Mon), 2016

 

Francis Mwimanzi, Macdonald Mahiti, Toyoda Mako, Jaclyn K Mann, Thumbi Ndung’u, Takamasa Ueno,  Immunological consequence of Nef-mediated HLA-I downregulation in vivo, Keystone Symposia : HIV Persistence and Eradication(X7),March 20(Sun) - 24(Thu), 2016

 

T Ueno, M Mahiti, F Mwimanzi, M Toyoda, Z Brumme, M Brockman, Relative resistance of HLA-B to downregulation by naturally occurring HIV-1 Nef sequences,Keystone Symposia : HIV Persistence : Pathogenesis and Eradication(X7), March 20(Sun) - 24(Thu), 2016

  

2015年

 

豊田真子, 前田洋介, 上野貴将,HIV-1 Nefによるウイルスレセプター発現抑制と重複感染の制御,the 29th Annual Meeting of the Japanese Society for AIDS Research,November 30th (Mon) – December 1st (TUE), 2015

 

Mako Toyoda,Yosuke Maeda,Takamasa Ueno,Protection of HIV-1 superinfection by primary Nef clones isolated from variousdisease status,HIV-1感染者由来のNef による重複感染の防御The 63rd Annual Meeting of the Japanese Society for Virology,November 22(Sun)-24(Tue), 2015

 

Francis Mwimanzi, Macdonald Mahiti, Toyoda Mako, Takamasa Ueno, Evaluation of HLA class I down-regulation function of HIV-1 Nef across viral subtypes, 44th Annual Meeting for Japanese Society for Immunology, Sapporo,18th-20th November,2015

 

Macdonald Mahiti, Zabrina Brumme, Heiko Jessen, Mark Brockman, Takamasa Ueno,  Nef-mediated immune evasion activities of HLA class II-restricted antigen presentation44th Annual Meeting for Japanese Society for Immunology, Sapporo,18th-20th November,2015

  

Mako Toyoda, Yosuke Maeda, Macdonald Mahiti, Xiaomei T. Kuang, Heiko Jessen, Bruce D. Walker, Mark A. Brockman, Zabrina L.Brumme, Takamasa Ueno,Differential ability of primary HIV-1 Nef isolates to down-regulate HIV-1 entry receptors and acquire superinfection resistance ,16th KUMAMOTO AIDS Seminar,October 7- 9, 2015

 

Francis Mwimanzi, Mako Toyoda, Macdonald Mahiti, Jaclyn K Mann, Bruce D. Walker, Thumbi Ndung'u, Takamasa Ueno,Evaluation of HLA class I down-regulation function of HIV-1 Nef across viral subtypes,16th KUMAMOTO AIDS Seminar,October 7- 9, 2015

 

Macdonald Mahiti, Heiko Jessen, Mark A. Brockman, Zabrina L.Brumme, Takamasa Ueno, Nef-induced immune evasion functions of HLA class II-restricted responses, 16th KUMAMOTO AIDS Seminar,October 7- 9, 2015

 

Takamasa Ueno, Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina Brumme, Mark A. Brockman,Relative resistance of HLA-B to down regulation by naturally-occurring HIV-1 Nef sequences, 16th KUMAMOTO AIDS Seminar,October 7- 9, 2015

 


Kamori D, Murakami T, Hasan Z, Meribe S,  Carlson J, Siarot L, Miura T, Kawana-Tachikawa  A, Iwamoto A, Gatanaga H, Oka S, Aida Y, Ueno T. Effects of natural variability of Vpr on immunological footprints and protein functions. Keystone Symposia HIV Vaccines (X5), March 22-27, 2015.

 

Mahiti M, Jia X, Toyoda M, Mwimanzi F, Walker BD, Brumme ZL, Brockman MA, Xiong Y, Ueno T. Differential down-regulation of the HLA class I allotypes by HIV-1 Nef primary isolate. The annual Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, Washington, USA Feb 23-26, 2015

 

Toyoda M, Ogata Y, Mahiti M, Pereyra F, Miura T, Walker BD, Brumme ZL, Brockman MA, Ueno T. Dynamic range of down-regulation of HIV-1 entry receptors by primary Nef isolates.  The annual Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, Washington, USA Feb 23-26, 2015

 

2014年

 

Mahiti M, M. Toyoda M, Mwimanzi F, Walker BD, Brumme ZL, Brockman MA, Ueno T.  HIV-1 Nef differentially recognizes the cytoplasmic tails of HLA-A and HLA-B molecules for down-regulation. The 43rd Annual Meeting for Japanese Society of the Immunology. Kyoto, Japan, Dec 10-12, 2014

 

Toyoda M, Ogata Y, Mahiti M, Pereyra F, Walker BD, Brumme ZL, Brockman MA, Ueno T. Analysis of naturally-occurring polymorphisms of HIV-1 Nef that impair CD4 and CCR5 down-regulation activity. The 28th Annual Meeting of the Japanese Society for AIDS Research, Osaka, Japan. Dec 3-5, 2014

 

Toyoda M, Ogata Y, Mahiti M, Pereyra F, Walker BD, Brumme ZL, Brockman MA, Ueno T. Analysis of the functional domains of Nef derived from HIV-1 elite controllers. The 62nd Annual Meeting of the Japanese Society for Virology, Yokohama, Japan. Nov 10-12, 2014

 

Kamori D, Murakami T, Hasan Z, Meribe S,  Carlson J, Siarot L, Miura T, Kawana-Tachikawa  A, Iwamoto A, Gatanaga H, Oka S, Aida Y, Ueno T. Effects of natural variability of an immunodominant Vpr region on immunological footprints, clinical outcome and protein functions. The 62nd Annual Meeting of the Japanese Society for Virology, Nov 10-12, 2014.

 

Toyoda M, Ogata Y, Pereyra F, Walker BD, Brumme ZL, Brockman MA, Ueno T. Differential modulation of Nef-mediated down-regulation of viral entry receptors is mediated by multiple sequence motifs in HIV-1 elite controllers. 15th Kumamoto AIDS Seminar, Kumamoto, Japan. Oct 01-03, 2014

 

Mahiti M, Toyoda M, Mwimanzi F, Walker BD, Brumme ZL, Brockman MA. Ueno T. Naturally- isolated HIV-1 Nef differentially recognize the cytoplasmic tails of HLA-A and HLA-B molecules for down-regulation. 15th Kumamoto AIDS Seminar, Kumamoto, Japan. Oct 01-03, 2014 

 

Doreen Kamori, T. Murakami, Z. Hasan, J. Carlson, L. Siarot, T. Miura, A. Kawana-Tachikawa, A. Iwamoto, H. Gatanaga, S. Oka, Y. Aida, T. Ueno. Effects of naturally-arising mutations in HLA-A*02-restricted immunodominant region on the functions of HIV-1 Vpr、第16回白馬シンポジウムin熊本、山崎記念会館、2014年6月13日‐14

 

豊田真子, 緒方陽子, Mahiti, Macdonald Pereyra, Florencia, Walker, Bruce, Brumme, Zabrina, Brockman, Mark, 上野貴将HIV-1感染者由来のNefを用いた機能ドメインの解析、第16回白馬シンポジウムin熊本、山崎記念会館、2014年6月13日‐14

 

Macdonald Mahiti, M.Toyoda, F.Mwimanzi, B.D.Walker, Z.L.Brumme, M.A.Brockman, T. Ueno. Natural variability of HIV-1 Nef responsible for selective recognition of the HLA-A over HLA-B molecules for down-regulation、第16回白馬シンポジウムin熊本、山崎記念会館、2014年6月13日‐14

 

Stanley C. Meribe, Zafrul Hasan, Hiroyuki Gatanaga, Toshiyuki Miura, Ai Kawana-Tachikawa, Aikichi Iwamoto, Shinichi Oka, Takamasa Ueno. Linkage between disease status and a naturally-arising mutation in functional region of HIV-1 Nef. The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014), March 3-6, 2014, Boston, Massachusetts, USA.

 

豊田真子, Philip Mwimanzi, Tristan Markle, Bruce D. Walker, Zabrina L. Brumme, Mark A. Brockman, 上野貴将. HIV-1感染者由来のNefを用いた機能ドメインの解析 日本薬学会第134年会:熊本2014年3月28-31日

 

2013年

 

Stanley C. Meribe, Ai Kawana-Tachikawa, Takamasa Ueno. Naturally arising amino-acid polymorphisms within functional regions of HIV-1 nef influence viral persistence in vivo. Annual meeting of the Japanese Society for Immunology, Dec 11-13, 2013

 

Stanley C. Meribe, Zafrul Hasan, Hiroyuki Gatanaga, Toshiyuki Miura, Ai Kawana-Tachikawa, Aikichi Iwamoto, Shinichi Oka, Takamasa Ueno. Effects of naturally occurring polymorphisms in functional domains of HIV-1 nef on in vivo disease progression. The 27th Annual meeting of Japanese Society for AIDS Research–“Towards the HIV/AIDS-free generation”, Nov 20-22, 2013

 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Differential modulation of Nef-mediated downregulation activity of HLA-A and B in HIV-1 chronic infection. The 27th Annual meeting of Japanese Society for AIDS Research–“Towards the HIV/AIDS-free generation”, Nov 20-22, 2013

 

豊田真子、Mwimanzi, Philip、Markle, Tristan、緒方陽子、Mahiti, Macdonald、Brumme, Zabrina、Brockman, Mark、上野貴将:HIV-1感染者由来のNefを用いた機能ドメインの解析、第27回日本エイズ学会学術集会・総会-熊本、2013年11月20日‐11月22日

 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Impact of naturally-occurring HIV-1 polymorphisms on differential modulation of Nef-mediated down-regulation between HLA class I loci. 61st Annual Meeting of the Japanese Society for Virology,  Kobe International Conference Center, Kobe, Japan. November 10th-12th, 2013

 

Stanley C. Meribe, Zafrul Hasan, Hiroyuki Gatanaga, Toshiyuki Miura, Ai Kawana-Tachikawa, Aikichi Iwamoto, Shinichi Oka, Takamasa Ueno. Acceleration of disease Progression by a single naturally-arising polymorphism, within functional region of HIV-1 nef. 14th Kumamoto AIDS Seminar, Oct 29-31, 2013

 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Differential modulation of Nef-mediated downregulation activity of HLA class I alleles in HIV-1 chronic infection. 14th Kumamoto AIDS Seminar, Kumamoto, Japan. October 29-31, 2013

 

Doreen Kamori, Zafrul Hasan, Hiroyuki Gatanaga, Shinichi Oka, Toshiyuki Miura, Aikichi Iwamoto, Ai Kawana-Tachikawa, Takamasa Ueno. HLA-A*02 allelic variants differently influence amino acid polymorphisms in an immunodominant epitope of HIV-1 Vpr. 14th Kumamoto AIDS Seminar, Kumamoto, Japan. October 29-31, 2013

 

Mako Toyoda, Philip Mwimanzi, Macdonald Mahiti, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Analysis of naturally-occurring polymorphisms of HIV-1 Nef that impair CD4 down-regulation activity. 14th Kumamoto AIDS Seminar, Oct 29-31, 2013

 

X. Kuang, A Le, P Mwimanzi, T Markle, R Danroth, T Ueno, T Miura, B Walker, Z Brumme, M Brockman, and the Acute HIV and International HIV Controllers study group. Reduced HIV-1 Nef Function in Acute/Early Individuals who become Viremic Controllers. 20th Conference on Retroviruses and Opportunistic Infections (CROI), Georgia World Congress Center, Atlanta, USA. March 3-6, 2013

 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Differential Nef-mediated down-regulation of HLA-A and B in chronic HIV-1 infection. Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications (D2), [Breckenridge, Colorado USA]  April 3-8, 2013

 

本園千尋, John J. Miles, Zafrul Hasan, 潟永博之, Stanley C. Meribe, David A. Price,岡慎一, 宮澤正顕, Andrew K. Sewell, 上野貴将: T細胞の交差反応性とHIV逃避変異の解析、白馬シンポジウム、7月19~20日、名古屋

 

Macdonald Mahiti, Philip Mwimanzi, Yoko Ogata, Michiyo Tokunaga, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Naturally-arising amino acid polymorphisms of HIV-1 Nef that differentially modulate downregulation of HLA-A and HLA-B molecules. Frontiers of Retrovirology conference, at Churchill College, Cambridge, UK. September 16th -18th 2013

 

2012年

 

上野貴将:HIV-1 Nefの遺伝子多型性と機能的可塑性、第14回白馬シンポジウムin京都、京都市国際交流会館、2012年6月7日‐6月8日

 

緒方陽子、Philip Mwimanzi、徳永美知代、Tristan Markle、三浦聡之、Bruce Walker、Zabrina Brumme、Mark Brockman、上野貴将:Nefのウイルスレセプター発現低下機能と病態、第14回白馬シンポジウムin京都、京都市国際交流会館、2012年6月7日‐6月8日

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, S. Oka, Z. Brumme, Takamasa Ueno. Impact of HLA class I-driven genetic variability in HIV-1 accessory gene vpu. COLD SPRING HARBOR ASIA CONFERENCES: Frontiers of Immunology in Health and Disease. Suzhou Dushu Lake Conference Center, China. September 3 - 7, 2012.

 

本園千尋、John J. Miles、宮澤正顯、上野貴将、Andrew K. Sewell: HLA-B35拘束性HIV特異的TCRは野生型抗原に高い特異性を有する、学術賞ならびに学術奨励賞候補口演、第21回組織適合性学会大会、明治大学、東京、2012年9月15~17日

 

T. Ueno. Functional impairment of HIV-1 Nef in elite controllers and its correlation with immune-mediated selective pressure. 13th Kumamoto AIDS Seminar Global COE Joint International Symposium, Kumamoto, Japan. October 24th - October 26th, 2012.

 

Zafrul Hasan, J. Carlson, H. Gatanaga, A. Le, C. Brumme, S. Oka, Z. Brumme, Takamasa Ueno. HLA class I-mediated sequence polymorphism in HIV-1 accessory protein Vpu. The 13th KUMAMOTO AIDS Seminar and GCOE Joint International Symposium, Hotel Nikko Kumamoto and Aso Resort Grandvrio Hotel, Kumamoto, Japan. October 24-26, 2012.

 

M. Mahiti, P. Mwimanzi, Y. Ogata, M. Tokunaga, B. Walker, Z. Brumme, M. Brockman, T. Ueno. Modulation of HIV-1 Nef-mediated HLA class I down-regulation activity during disease progression. 13th Kumamoto AIDS seminar Aso Resort Grandiovrio Hotel, Kumamoto, Japan 24th -26th October, 2012.

 

Chihiro Motozono, John J. Miles Zafrul Hasan Hiroyuki Gatanaga, Meribe Stanley. C, Shinichi Oka, Masaaki Miyazawa, Andrew K. Sewell, and Takamasa Ueno. HIV-1 immune escape and cross-reactivity profiles of virus-specific cytotoxic T lymphocytes, YIS-A Session II, 13th Kumamoto AIDS Seminar Global COE Joint International Symposium, Aso Resort GRANDVRIO, Kumamoto, Japan, October 24-26, 2012

 

上野貴将、Mwimanzi Philip、Markle Tristan、緒方陽子、徳永美知代、Mahiti Macdonald、三浦聡之、Pereyra Florencia、Walker Bruce、Brumme Zabrina、Brockman Mark:Genetic and functional analyses of HIV-1 Nef in elite controllers.第60回日本ウイルス学会学術集会、グランキューブ大阪(大阪国際会議場)、2012年11月13日‐11月15日

 

緒方陽子、Philip Mwimanzi、李小光、徳永美知代、Tristan Markle、三浦聡之、Bruce Walker、Zabrina Brumme、Mark Brockman、上野貴将:Nefのウイルスレセプター発現低下機能と病態、第26回日本エイズ学会学術集会・総会、慶應義塾大学日吉キャンパス、2012年11月24日‐11月26日

 

Chihiro Motozono, John S. Bridgeman, Masaaki Miyazawa, Andrew K. Sewell and Takamasa Ueno. The impact of a single amino acid difference in CDR3a on TCR ab cross-reactivity、ワークショップ32 ヒト免疫、第41回日本免疫学会総会・学術集会、神戸、兵庫、2012年12月5~7日

 

 

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