研究成果
Philip Mwimanzi
・ Global Health Travel Award at Keystone Symposia (HIV Vaccine), March 21-26, 2010, Banff, Alberta, Canada
・ Global Health Travel Award at Keystone Symposia (HIV Vaccine), March 22-27, 2009, Keystone CO, USA
・ Travel Bursary at the 14th International Congress of Immunology (ICI 2010), August 22-27, 2010 in Kobe, Japan
論文
1. Takamasa Ueno, Chihiro Motozono, Sachi Dohki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi, Oka, Masafumi Takiguchi (2008) CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef. Journal of Immunology 180, 1107-1116
http://jimmunol.org/content/180/2/1107
2. Chihiro Motozono, Philip Mwimanzi, Takamasa Ueno (2010) Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection. Protein & Cell 1, 514-519
http://link.springer.com/article/10.1007/s13238-010-0068-0
3. Philip Mwimanzi, Zafrul Hasan, Michiyo Tokunaga, Hiroyuki Gatanaga, Shinichi Oka, Takamasa Ueno (2010) Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection. Biochem. Biophys. Res. Comm. Volume 403, 422-427
http://jvi.asm.org/content/84/11/5508
4. Philip Mwimanzi, Zafrul Hasan, Ranya Hassan, Shinya Suzu, Masafumi Takiguchi and Takamasa Ueno (2011) Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. Retrovirology 8:50 doi:10.1186/1742-4690-8-50
http://www.retrovirology.com/content/8/1/50
5. Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T. Fackler, Seiji Okada, Shinya Suzu (2011) The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement. PLoS ONE 6(11): e27696
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027696
6. Philip Mwimanzi, Tristan J. Markle, Takamasa Ueno, Mark A. Brockman (2012) HLA class I down-regulation by HIV-1 Nef: What might we learn from natural sequence variants? Viruses 4, Issue 10 (October 2012), 1711-1730 doi:10.3390/v4091711
http://www.mdpi.com/1999-4915/4/9/1711
7. Philip Mwimanzi, Tristan J Markle, Eric Martin, Yoko Ogata, Xiaomei T Kuang, Michiyo Tokunaga, Macdonald Mahiti, Florencia Pereyra, Toshiyuki Miura, Bruce D Walker, Zabrina L Brumme, Mark A Brockman and Takamasa Ueno (2013) Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology 10: 1 DOI: 10.1186/1742-4690-10-1
http://www.retrovirology.com/content/8/S2/P53
8. Philip Mwimanzi, Tristan J Markle, Yoko Ogata, Eric Martin, Michiyo Tokunaga, Macdonald Mahiti, Xiaomei T Kuang, Bruce D Walker, Zabrina L Brumme, Mark A Brockman and Takamasa Ueno (2013) Dynamic range of Nef functions in chronic HIV-1 infection. Virology, 439, 74-80 DOI: 10.1016/j.virol.2013.02.005
http://www.sciencedirect.com/science/article/pii/S0042682213000913
学会発表
【国際学会での発表】
1. Philip Mwimanzi, Masafumi Takiguchi, and Takamasa Ueno. Keystone Symposia HIV Vaccines (X5), Fairmont Banff Springs, Banff, Alberta, Canada, March 21-26, 2010. Presented poster titled: CTL-escape Nef variants influence CCR5 down-regulation and HIV superinfection susceptibility.
2. Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno Impairment of virion infectivity by nef alleles from HIV elite controllers. Keystone Symposia HIV Evolution, Genomics and Pathogenesis (X7), Whistler Conferene center, Whistler, Canada, March 20-25, 2011.
3. Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno Impairment of virion infectivity by nef alleles from HIV elite controllers. Nef activity in enhancement of virion infectivity is impaired in HIV elite controllers. XV, International Congress of Virology, Sapporo, Japan, 11-16 September 2011.
4. Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman,Takamasa Ueno Impairment of viral replication capacity by nef alleles from HIV elite controllers. Frontiers of Retrovirology, Complex retroviruses, retroelements and their hosts, Amsterdam, Netherlands, 3-5 October 2011.
5. Mwimanzi Philip and Ueno Takamasa. The 14th International Conference of Immunology (ICI), Kobe International Exhibition and Portopia Hotel, Kobe, Japan. August 23-27, 2010. Presented a poster titled: CTL-escape Nef variants influence CCR5 down regulation and HIV superinfection susceptibility.
【国内学会・セミナー等での発表】
1. Mwimanzi Philip, Hassan Ranya, Suzu Shinya, Takiguchi Masafumi, Ueno Takamasa. 10th Kumamoto AIDS Seminar-GCOE Joint International Symposia, Hotel Nikko, Kumamoto, Japan. September 28-29, 2009. Presented poster titled: The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.
2. Philip Mwimanzi, Masafumi Takiguchi, and Takamasa Ueno. 23rd Annual Meeting of Japanese Society for AIDS Research, Nagoya Congress Center, Nagoya, Japan November 26-28, 2009. Presented oral presentation titled: CTL escape Nef variants influence CCR5 down regulation and HIV superinfection susceptibility in primary human macrophages.
3. Mwimanzi Philip, Hassan Ranya, Suzu Shinya, Takiguchi Masafumi, Ueno Takamasa. International Young Investigators Symposia (IYIS), Kumamoto University, Kumamoto, Japan. March 04-05, 2010. Presented and oral presentation titled: The effects of CTL-escape conferring mutations on Nef's pathogenic functions in primary macrophages.
4. Mwimanzi, P., Oniangue-Ndza, C., Allen T.M., and Ueno,T. Nef activity in down regulation of viral receptors and protection of HIV superinfection is modulated by Nef mutations that confer CTL escape during acute infection. 11th KUMAMOTO AIDS Seminar GCOE Joint International Symposium, Hotel Nikko Kumamoto and Aso Grand Vrio Hotel, Kumamoto, Japan, October 6-8, 2010.
5. Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Population analysis of viral replication capacity by nef alleles of HIV elite controllers. 12th Kumamoto AIDS Seminar, Kumamoto, Japan, 19-21 October 2011.
6. Philip Mwimanzi, Tristan Markle, Michiyo Tokunaga, Toshiyuki Miura, Eric Martin, Florencia Pereyra, Bruce Walker, Zabrina Brumme, Mark Brockman, Takamasa Ueno. Impaired viral infectivity and viral replication capacity by nef alleles from HIV elite controllers. 25th Annual Meeting of Japanese Society for AIDS Research, Tokyo Hyatt Regency, Tokyo, Japan. November 30th - 2nd December, 2011.
