研究成果
研究室の成果（論文）
2015年
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D Walker, Yong Xiong, Zabrina L Brumme, Mark A Brockman, Takamasa Ueno (2016) Relative resistance of HLA-B to down-regulation by naturally occurring HIV-1 Nef sequences. mBio 7(1): e01516-15 doi: 10.1128/mBio.01516-15
Mako Toyoda, Yoko Ogata, Macdonald Mahiti, Yosuke Maeda, Xiaomei T. Kuang, Toshiyuki Miura, Heiko Jessen, Bruce D. Walker, Mark A. Brockman, Zabrina L. Brumme, Takamasa Ueno (2015) Differential ability of primary HIV-1 Nef isolates to down-regulate HIV-1 entry receptors. J Virol. 89, 9639-9652 doi:10.1128/JVI.01548-15
Macdonald Mahiti, Zabrina L Brumme, Heiko Jessen, Mark A Brockman, Takamasa Ueno (2015) Dynamic range of Nef-mediated evasion of HLA class II-restricted immune responses in early HIV-1 infection. Biochem. Biophys. Res. Comm. in press DOI: 10.1016/j.bbrc.2015.05.038
Stanley C. Meribe, Zafrul Hasan, Macdonald Mahiti, Francis Mwimanzi, Mako Toyoda, Masahiko Mori, Hiroyuki Gatanaga, Tadashi Kikuchi, Toshiyuki Miura, Ai Kawana-Tachikawa, Aikichi Iwamoto, Shinichi Oka, Takamasa Ueno (2015) Association between a naturally-arising polymorphism within functional region of HIV-1 Nef and disease progression in chronic HIV-1 infection. Virol. in press DOI: 10.1007/s00705-015-2480-5
2014年
Saeko Yanaka, Takamasa Ueno, Yi Shi, Jianxun Qi, George F. Gao, Kouhei Tsumoto, Kenji Sugase (2014) Peptide-dependent conformational fluctuation determines the stability of the human leukocyte antigen class I complex. J Biol, Chem. in press
http://www.jbc.org/content/early/2014/07/15/jbc.M114.566174.full.pdf+html
Xiaomei Kuang, Xiaoguang Li, Gursev Anmole, Philip Mwimanzi, Aniqa Shahid, Anh Le, Louise Chong, Hua Qian, Toshiyuki Miura, Tristan Markle, Bemuluyigza Baraki, Elizabeth Connick, Eric Daar, Heiko Jessen, Anthony Kelleher, Susan Little, Martin Markowitz, Florencia Pereyra, Eric S. Rosenberg, Bruce Walker, Takamasa Ueno, Zabrina Brumme, and Mark Brockman (XK and XL equally contributed as first authors. TU, ZB, and MB contributed as senior authors.) Journal Virology, in press
Zafrul Hasan, Doreen Kamori and Takamasa Ueno （ZH and DK contributed equally as first authors) Role of host immune responses in sequence variability of HIV-1 Vpu. World J Immunol 2014;4(2):107-115
http://www.wjgnet.com/2219-2824/full/v4/i2/107.htm
2013年
Philip Mwimanzi, Tristan J Markle, Eric Martin, Yoko Ogata, Xiaomei T Kuang, Michiyo Tokunaga, Macdonald Mahiti, Florencia Pereyra, Toshiyuki Miura, Bruce D Walker, Zabrina L Brumme, Mark A Brockman and *Takamasa Ueno (2013) Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology 10: 1 DOI: 10.1186/1742-4690-10-1
http://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-10-1
Philip Mwimanzi, Tristan J Markle, Yoko Ogata, Eric Martin, Michiyo Tokunaga, Macdonald Mahiti, Xiaomei T Kuang, Bruce D Walker, Zabrina L Brumme, Mark A Brockman and *Takamasa Ueno (2013) Dynamic range of Nef functions in chronic HIV-1 infection. Virology, 439, 74-80 DOI: 10.1016/j.virol.2013.02.005
http://www.sciencedirect.com/science/article/pii/S0042682213000913
Chihiro Motozono, John J. Miles, Zafrul Hasan, Hiroyuki Gatanaga, Stanley C. Meribe, David A. Price, Shinichi Oka, Andrew K. Sewell, *Takamasa Ueno (2013) CD8+ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope. PLoS ONE 8(6): e66152. doi:10.1371/journal.pone.0066152
http://www.plosone.org/article/info:doi/10.1371/journal.pone.0066152
2012年
Zafrul Hasan, Jonathan M Carlson, Hiroyuki Gatanaga, Anh Q. Le, Chanson J Brumme, Shinichi Oka, Zabrina L Brumme, *Takamasa Ueno (2012) Minor contribution of HLA class I-associated selective pressure to the variability of HIV-1 accessory protein Vpu. Biochem. Biophys. Res. Comm. 421, 291-295 DOI: 10.1016/j.bbrc.2012.04.002
http://www.sciencedirect.com/science/article/pii/S0006291X12006365
Philip Mwimanzi, Tristan J. Markle, *Takamasa Ueno, Mark A. Brockman (2012) HLA class I down-regulation by HIV-1 Nef: What might we learn from natural sequence variants? Viruses 4, Issue 10 (October 2012), 1711-1730 doi:10.3390/v4091711
http://www.mdpi.com/1999-4915/4/9/1711
2011年
Philip Mwimanzi, Zafrul Hasan, Ranya Hassan, Shinya Suzu, Masafumi Takiguchi and *Takamasa Ueno (2011) Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. Retrovirology 8:50 doi:10.1186/1742-4690-8-50
http://www.retrovirology.com/content/8/1/50
Nopporn Chutiwitoonchai, Masateru Hiyoshi, Philip Mwimanzi, *Takamasa Ueno, Akio Adachi, Hirotaka Ode, Hironori Sato, Oliver T. Fackler, Seiji Okada, Shinya Suzu (2011) The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement. PLoS ONE 6(11): e27696
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0027696
2010年
Koizumi H, Hashimoto M, Fujiwara M, Murakoshi H, Chikata T, Borghan MA, Hachiya A, Kawashima Y, Takata H, *Ueno T, Oka S, Takiguchi M. (2010) Different in vivo effects of HIV-1 immunodominant epitope-specific CTLs on selection of escape mutant viruses. Journal of Virology 84, 5508-5519
http://jvi.asm.org/content/84/11/5508
Chihiro Motozono, Philip Mwimanzi, *Takamasa Ueno (2010) Dynamic interplay between viral adaptation and immune recognition during HIV-1 infection. Protein & Cell 1, 514-519
http://link.springer.com/article/10.1007/s13238-010-0068-0
Philip Mwimanzi, Zafrul Hasan, Michiyo Tokunaga, Hiroyuki Gatanaga, Shinichi Oka, *Takamasa Ueno (2010) Naturally arising HIV-1 Nef variants conferring escape from cytotoxic T lymphocytes influence viral entry co-receptor expression and susceptibility to superinfection. Biochem. Biophys. Res. Comm. Volume 403, 422-427
http://www.sciencedirect.com/science/article/pii/S0006291X10021066
2009年
Chihiro Motozono, Saeko Yanaka, Kouhei Tsumoto, Masafumi Takiguchi, *Takamasa Ueno (2009) Impact of intrinsic cooperative thermodynamics of peptide-MHC complexes on antiviral acivity of HIV-specific CTL. Journal of Immunology 182, 5528-5536
http://jimmunol.org/content/182/9/5528
Zheng N, Fujiwara M, *Ueno T, Oka S, Takiguchi M. (2009) Strong ability of Nef-specific CD4+ cytotoxic T cells to suppress HIV-1 replication in HIV-1-infected CD4+ T cells and macrophages. Journal of Virology 83, 7668-7677
http://jvi.asm.org/content/83/15/7668
Ranya Hassan, Shinya Suzu, Masateru Hiyoshi, Naoko Takahashi-Makise, *Takamasa Ueno, Tsutomu Agatsuma, Hirofumi Akari, Jun Komano, Yutaka Takebe, Kazuo Motoyoshi, and Seiji Okada (2009) Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. Journal of Cellular Physiology, 221, 458-468
2008年
*Takamasa Ueno, Chihiro Motozono, Sachi Douki, Philip Mwimanzi, Susanne Rauch, Oliver T. Fackler, Shinichi Oka, and Masafumi Takiguchi. CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef. J.Immunol. 180: 1107-1116, 2008.
http://jimmunol.org/content/180/2/1107
2007年
*Takamasa Ueno, Yuka Idegami, Chihiro Motozono, Shinichi Oka, and Masafumi Takiguchi. Altering Effects of Antigenic Variations in HIV-1 on Antiviral Effectiveness of HIV-specific CTLs. J.Immunol. 178: 5513-5523, 2007.
http://jimmunol.org/content/178/9/5513
